Transparency Document

NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate V.2.2025

Request Number Guideline Page Specific change request Panel Decision Comment Institution Vote
3843 CRIT-6
Prostate Submission from Invitae Corporation on 03-26-2024

For bullet point: “Personal history of prostate cancer with specific features:”

Proposed change: Remove “with specific features” from bullet point and all subsequent bullet points in the “Personal history” section. 


Change not made Yes: 0
No: 33
Abstain:0
Absent:0
3844 TITLE
Prostate Submission from Invitae Corporation on 03-26-2024

Specific changes proposed: Guideline Title: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic 

Proposed change: Add Prostate to the Title: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate 


Change made Yes: 34
No: 0
Abstain:0
Absent:0
2741 CRIT-6
Testing Criteria Submission from Myriad Genetics, Ambry Genetics, Illumina Inc., Quest Diagnostics on 03-07-2024

We request that the following criteria be added to the Testing Criteria for Prostate Cancer to make them consistent with the prior testing criteria in the NCCN Prostate Cancer guideline v4.2023 (page PROS-C 2 of 3):

 

On page CRIT-6, under the second arrow (“By family history and ancestry”) please add:

  • >1 close relative with:
    • Colorectal or endometrial cancer at age <50y
  • >1 first-degree relative with:
    • Prostate cancer at age <60 y
  • A known family history of a familial cancer risk mutation (pathogenic/likely pathogenic variant).
Change not made Yes: 0
No: 34
Abstain:0
Absent:0