NCCN Drugs & Biologics Compendium
The NCCN Compendium® contains authoritative, scientifically derived information designed to support decision-making about the appropriate use of drugs and biologics in patients with cancer.
The recommendations for appropriate use of drugs and biologics contained in the NCCN Compendium are extracted directly from the relevant NCCN Guidelines along with their clinical context, route of administration, recommended use, and NCCN category of evidence.
The uses identified are based upon evaluation of evidence from scientific literature integrated with expert judgment in an evidence-based process. Indicated uses are categorized in a systematic approach that describes the type of evidence available for and the degree of consensus underlying each recommendation.
All recommendations (at all category levels) in the NCCN Compendium constitute appropriate, medically-necessary care. The NCCN Compendium lists both FDA-approved uses and appropriate uses beyond the FDA-approved label.
New features and enhancements! NCCN continues to enhance its suite of clinical decision-making resources used across the oncology community to help people with cancer. New features within the NCCN Drugs & Biologics Compendium (NCCN Compendium®) improve search functionality and a new dropdown menu integrates information directly from the NCCN Chemotherapy Order Templates (NCCN Templates®). Users can seamlessly search within the NCCN Compendium® for the NCCN Templates® ID and regimen name (plus course title if applicable), further improving access to information on safe handling of cancer drugs and biologics. Users can now quickly and easily find the information they need using free-text search functionality across all dropdown menus. As always, the NCCN Compendium continues to be a continuously updated and expanding database in parallel with the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®).
Creating the NCCN Compendium
NCCN oncology pharmacists generate the NCCN Compendium at the agent level rather than regimen; however, these agents reflect the components of regimens used in disease management. Regimen-level information is available and searchable in a separate column. In addition to Guidelines specific indication and use, NCCN adds relevant information such as pharmacologic class, relevant ICD-10 codes, and FDA indications to the searchable database. Compendium development and maintenance is accomplished by disease type and reviewed by members of the relevant NCCN panel before publication.
How the NCCN Compendium is used
The NCCN Compendium is recognized by public and private insurers alike, including, but not limited to the Centers for Medicare and Medicaid Services (CMS) and UnitedHealthcare as an authoritative reference for oncology coverage policy.
Managed care medical directors, pharmacy benefits directors, and other health care professionals also reference the NCCN Compendium when making decisions that impact patient access to appropriate therapy.
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NCCN EXPLICITLY DISCLAIMS THE APPROPRIATENESS OR APPLICABILITY OF THE NCCN CONTENT, THE NCCN GUIDELINES, AND ANY DERIVATIVE RESOURCES, OR THE USE OR APPLICATION OF THE NCCN CONTENT, THE NCCN GUIDELINES OR ANY SUCH DERIVATIVE RESOURCES, TO ANY SPECIFIC PATIENT'S CARE OR TREATMENT. ANY CLINICIAN SEEKING TO APPLY OR CONSULT THE NCCN CONTENT, THE NCCN GUIDELINES AND/OR ANY DERIVATIVE RESOURCES IS EXPECTED TO USE INDEPENDENT MEDICAL JUDGMENT IN THE CONTEXT OF THE INDIVIDUAL CLINICAL CIRCUMSTANCES TO DETERMINE ANY PATIENT'S CARE OR TREATMENT.