NCCN At a Glance

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of 33 leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to defining and advancing quality, effective, equitable, and accessible cancer care and prevention so all people can live better lives.

NCCN Chief Executive Officer Crystal S. Denlinger, MD, is a board-certified oncologist who previously served as NCCN Senior Vice President, Chief Scientific Officer, Chair of the NCCN Guidelines Panel for Survivorship, and Member of the NCCN Guidelines Panels for Bone Cancer; Esophageal/Gastric Cancers; Occult Primary Cancers; and Older Adult Oncology.  

NCCN’s headquarters are located in Plymouth Meeting, PA, outside Philadelphia.

In 2025, NCCN is marking its 30th anniversary. 

What NCCN Does

NCCN defines and advances high-quality, high-value, patient-centered cancer care for all people globally, through the creation and dissemination of cancer treatment guidelines and other content.

  • The 88 NCCN Guidelines® are developed by 63 panels, each comprised of clinician and researcher volunteers — resulting in input from more than 1,900 multidisciplinary members of the nation’s top 33 cancer centers. Many panels include patient advocates and other relevant professionals.
  • Although the NCCN Guidelines are based on the best available evidence, new data are always being published. For this reason, the NCCN Guidelines are updated continuously and developed through a completely transparent process that informs patients, clinicians, and payers of the evidence supporting treatment recommendations. This transparency allows decision-makers — physicians and patients — to understand the evidence upon which they make their treatment choices. In addition, each NCCN Guidelines undergoes annual institutional review which is circulated for comment among the multidisciplinary faculty at each NCCN Member Institution.
  • Of all U.S. physicians surveyed by NCCN, 95 percent report they use the NCCN Guidelines in their practices. In addition, payers, including but not limited to the two largest U.S. payers — UnitedHealthcare and the Centers for Medicare & Medicaid Services (CMS) — rely on the NCCN Guidelines to determine their oncology coverage policies.
  • In 2024, the NCCN Guidelines were downloaded more than 16 million times.
  • Approximately 48 percent of registered users of the NCCN Guidelines are international professionals, with the most users in China, India, South Korea, Brazil, Mexico, Japan, Thailand, Canada, Spain, and Italy.
  • NCCN Drugs & Biologics Compendium (NCCN Compendium®) contains authoritative, scientifically derived information designed to support decision-making about the appropriate use of drugs and biologics in patients with cancer. Users can seamlessly search within the NCCN Compendium® for the NCCN Templates® ID and regimen name (plus course title if applicable). The NCCN Compendium® is recognized by public and private insurers alike, including CMS and UnitedHealthcare as an authoritative reference for oncology coverage policy.
  • NCCN Biomarkers Compendium® contains information designed to support decision-making around the use of biomarker testing in patients with cancer.
  • NCCN Radiation Therapy Compendium™ contains information to support decision-making around the use of radiation therapy in patients with cancer. It also includes a link to normal tissue dose constraints for NCCN Guidelines that include this information.
  • NCCN Chemotherapy Order Templates (NCCN Templates®) include chemotherapy, immunotherapy, supportive care agents, monitoring parameters, and safety instructions based directly on recommendations within the NCCN Guidelines. Special instructions for self-administered chemotherapeutic agents are also provided.
  • NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™) include recommendations pertaining to cancer screening, diagnosis, staging, treatment response assessment, follow-up, and surveillance to support clinical decision-making for patients with cancer. NCCN is a CMS-approved Provider Led Entity for imaging AUC.

NCCN provides patients with the information they need to make the best treatment decisions possible.

  • There are more than 73 NCCN Guidelines for Patients®, versions of the NCCN Guidelines that provide people facing cancer and their loved ones with easy-to-understand information about treatment recommendations, and how to discuss them with their care team. There are more than 90 language translations available.
  • In 2024, there were more than 1.7 million downloads of the NCCN Guidelines for Patients.
  • NCCN Guidelines with NCCN Evidence Blocks™ provide a visual representation of five key value measures for treatment options in the NCCN Guidelines — efficacy, safety, quality and quantity of evidence, consistency of evidence, and affordability — in order to put patient values first in the shared decision-making process.
  • NCCN Guidelines with Categories of Preference for drugs and biologics distinguish between preferred interventions, recommended interventions, and those useful in certain circumstances.

NCCN secures funding for research that improves cancer care.

  • NCCN’s Oncology Research Program (ORP) has awarded a total $85.2 million. $73.8 million has been awarded to NCCN Member Institutions: $57.5 million for studies overseen by ORP and the remaining $16.3 million was managed by the grantor
  • Through donations and support, the NCCN Foundation® has funded 79 young investigators from across NCCN Member Institutions.

NCCN’s educational programming and publications influence health policy and inform the oncology community.

  • Each year, NCCN hosts three policy summits and one State Oncology Society Forum to encourage discussion among oncology stakeholders and address current health policy issues.
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