eBulletin Newsletter
NCCN Flash Update: NCCN Guidelines Updated for Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate
NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate. These NCCN Guidelines® are currently available as Version 2.2025.
Link directly to the Updates section of the NCCN Guidelines: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate
New Guideline Name
- Prostate added to Guideline name.
CRIT-6
- Testing Criteria for Prostate Cancer Susceptibility Genes
- Testing is clinically indicated in the following scenarios: Criteria updated and reorganized.
- 1st bullet added: Personal history of prostate cancer ≤55 y not meeting any of the above criteria. Corresponding footnote ee added: Referring to data (Ewing C, et al N Engl J Med 2012;366:141-149; Kote-Jarai Z, et al. Ann Oncol 2015;26:756-761; Witte JS, et al. Cancer Epidemiol Biomarkers Prev 2013;22:675-680) regarding early onset prostate cancer with HOXB13.
- New criteria added:
- Refer for genetic testing in the following scenario: Biochemical recurrence, For this heterogeneous disease state, refer for genetic testing if: 1) Very high-risk or high-risk disease at diagnosis (see above), 2) family history of cancer criteria met, or if (and at time of) progression to metastatic disease.
- Testing is clinically indicated in the following scenarios: Criteria updated and reorganized.
GENE-A (all pages)
- 3rd column, Prostate cancer added to header.
For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium®), the NCCN Biomarkers Compendium®, the NCCN Chemotherapy Order Templates (NCCN Templates®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.
To view the NCCN Guidelines for Patients®, please visit NCCN.org/patientguidelines.
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